Advances In Biochemical Engineering Biotechnology. Thermal by N/a

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50 . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 High Resolution Thin-Film Thermistors . . . . . . . . 2 Miniaturized Enzyme Thermistors . . . . . . . . . . 3 Integrated Thermopiles . . . . . . . . . . . . . 62 Advances in Biochemical Engineering / Biotechnology, Vol. 64 Managing Editor: Th. Scheper © Springer-Verlag Berlin Heidelberg 1999 36 F. Lammers · Th. 4 Bio-Thermochips . . . . . . . . . . . . . . . 5 Compact Multichannel Enzyme Thermistors .

36 2 Thermal Biosensors: Principles and State of the Art 3 Applications of Enzyme Thermistors – A Review . . . . . . 6 Clinical Analysis . . . . . . Immunoanalysis . . . . . Determination of Enzyme Activities Process Monitoring . . . . . Environmental Analysis . . . Enzymatic Amplification . . . 6 Enantiomeric Analysis . . . . . . . . . Aminoacid Analysis . . . . . . . . . . Medical Monitoring . . . . . . . . . . Kinetic Characterization of Immobilized Biocatalysts Monitoring of Enzyme Catalyzed Syntheses .

1994) manufactured a microbiosensor with an integrated thermopile on a quartz chip because of the lower heat conductivity of quartz compared to silicon. 6 mm, and immobilized enzymes (CPG beads) were were placed in the chips microchannels. The sensor was applied to glucose analysis in the 2 to 25 mmol/l range, using only 1 ml samples. Due to clinical analysis requirements, the sensor might be interesting for blood glucose measurements. Nevertheless, some problems have to be considered. First of all, it is very difficult to obtain non-clogging immobilization materials.

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