Amino Acids, Peptides and Proteins (SPR Amino Acids, by G. C. Barrett, J. S. Davies

By G. C. Barrett, J. S. Davies

Expert Periodical studies supply systematic and unique evaluate assurance of development within the significant parts of chemical study. Written by means of specialists of their expert fields the sequence creates a different provider for the energetic study chemist, providing normal severe in-depth money owed of growth specifically components of chemistry. In an ever-increasing area of task Amino Acids Peptides and Proteins offers an annual compilation of the world's examine attempt into this significant zone of organic chemistry. quantity 33 presents a evaluate of literature released in the course of 2000. Comprising a accomplished overview of important advancements at this biology/chemistry interface every one quantity opens with an summary of amino acids and their functions. paintings on peptides is reviewed over a number of chapters starting from present tendencies of their synthesis and conformational and structural research to peptidomimetics and the invention of peptide-related molecules in nature. the appliance of complicated ideas in structural elucidation is integrated into all chapters while periodic chapters on steel complexes of amino acids peptides and beta-lactams expand the scope of insurance. effective looking of professional themes is facilitated through the sub-division of chapters into discrete topic parts permitting annual traits to be monitored. All researchers within the pharmaceutical and allied industries and on the biology/chemistry interface in academia will locate this an crucial reference resource.

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Additional resources for Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 33)

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7 From Glycine Derivatives and Imines of Glycoxylic Acid Derivatives. The synthesis of amino acids from glycine derivatives has been reported. The oxazolidinones (15) (R : various alkyl or aryl) served as Michael acceptors in addition reactions with achiral Ni(II) complexes of glycine Schiff bases. g. 123 Imines of glycoxylic acid derivatives have also been employed in the synthesis of amino acids. Alkylations and condensation reactions of both glycine and alanine imine have been studied and were shown to give rise to enolates which could be alkylated in a highly diastereoselective manner.

454 Preferential crystallisation has been used for the resolution of ,- -alanine using -alanine seed crystal. 459 Enzymic techniques have been used extensively. 462 Immobilised chymotrypsin on hydrophilic macroporous support has been used for the resolution of ,-phenylalanine ethyl ester Schiff base. 467 Penicillin G acylase catalysed the acylation of the -isomers of methyl esters of phenylglycine and derivatives. The process allows the isolation of the enantiomerically pure -phenylglycine, suitable for conversion into -lactam antibiotics,468 and the pure diastereoisomers of 4-fluoroglutamine and 4-fluoroisoglutamine where prepared from the corresponding 4-fluoroglutamic acids.

429 The synthesis of ‘cyclic’ amino acids has also been described. These are mainly of two types, the pyrrole-type, where the amino acid nitrogen is included in a ring structure, or the cycloalkane-type, where the amino group and carboxylic acid group are attached to a ring. 5]decane-1-carboxylates (42) from 2-oxocyclopentanecarboxylate. 439 The syntheses of the methyl esters of the N-heteroamino-methylene malonic acids (43, A : 2-pyridyl, 2-(5-methylpyridyl), 2-pyrimidyl), which sublime to give oxopyidinopyrimidines,440 4-amino-3-(aminomethyl)benzoic acid, in three steps from 4-aminobenzoic acid441 and syn-1-vinyl-2-amino alcohol derivatives by addition of ( -alkoxyallyl)titaniums with chiral imines442 have been reported.

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