Fermentation and Biochemical Engineering Handbook. by Henry C. Vogel, Celeste M. Todaro

By Henry C. Vogel, Celeste M. Todaro

This is a well-rounded instruction manual of fermentation and biochemical engineering offering ideas for the industrial creation of chemical compounds and prescription drugs through fermentation. Emphasis is given to unit operations fermentation, separation, purification, and restoration. ideas, method layout, and kit are unique. atmosphere elements are covered.

The useful points of improvement, layout, and operation are under pressure. concept is incorporated to supply the mandatory perception for a specific operation. difficulties addressed are the gathering of pilot information, selection of scale-up parameters, collection of the proper piece of apparatus, pinpointing of most likely hassle spots, and strategies of troubleshooting.

The textual content, written from a pragmatic and working standpoint, will help improvement, layout, engineering and creation group of workers within the fermentation undefined. members have been chosen according to their commercial heritage and orientation. The publication is illustrated with a number of figures, photos and schematic diagrams.

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C) Percolated Impeller. (D) Draught Tube Air-lift. (B) Draft Tubewith KaplanTurbine. (F) Air-liftloop. (G)RotatingDrum. (H) LightEmitting Draught Tube. (1) Spin Filter. (J) BubbleColumn. (K) Aeration. (L) Gaseous Phase. ~ .... s~.... ol:l.. ~ • metabolite productivity Figure 19. Comparison of yield and productivity for cell mass and anthraquinones in various bioreactor systems. (1) Shake Flask. (2) Flat Blade Turbine. (3) Perfolated Disk Impeller. (4) Draft Tube Bioreactor with Kaplan Turbine.

Using 2 to 10 I bioreactors, it is also possible to produce 5,000 to 10,000 plantlets from plant tissue, which can then be transplanted directly into soil. 6 Culture Period The growth of plant cells, tissues, and organs is much slower than microbial organisms. The most rapid growth cell line reported in scientific journals is the bright yellow Nicotiana tabacum cv. 3 days) when cultured in a 20 kl pilot scale bioreactor. In general, the growth ofthe cells of herbaceous annual plants is rapid and their doubling time is usually about I to 3 days (duration to maximum growth was 10 to 20 days), and that of woody plants or differentiated organs is slow (doubling time is about 2 to 10 days and the culture period is about 20 to 100 days).

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